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柳长柏教授
[ 录入者:admin | 时间:2017-04-17 21:14:52 | 作者: | 来源: | 浏览:8057次 ]


    柳长柏,教授,医学博士。1990年毕业于哈尔滨医科大学取得传染病学硕士学位,1994年作为国家教委访问学者到日本大阪大学微生物学研究所访问研究,1995年考入日本东京大学医学部攻读博士学位,2000年取得东京大学医学博士学位,同年赴加拿大多伦多大学进行博士后研究。2005年11月回国受聘于三峡大学。目前任中国微生物学会干扰素与细胞因子专业委员会理事,宜昌市传染病与寄生虫学会常务委员以及《生命科学》、《生命的化学》等杂志审稿专家。

研究方向:

1 治疗基因及基因工程蛋白药物的靶向输送,载体开发(高效载药多肽的设计开发及在抗肿瘤、干细胞治疗等领域的应用);

2)肝纤维化等慢性肝病的分子发病机理及分子治疗靶点探索。

发表论文:   

1.       YQ Zhang, LY Wan, XM He, YR Ni, C Wang, CB Liu*, JF Wu*. Gremlin1 Accelerates Hepatic Stellate Cell Activation Through Upregulation of TGF-Beta Expression. DNA CELL BIOL. 2017, 5. (Q4, SCI IF: 2.574)

2.       Zeng XY, Zhang YQ, He XM, Wang H, Liu YL, Zhang PY, Zhou XL, Wu JF*, Liu CB*. MicroRNA-23/27 Clusters Target Gremlin 1 to Modulate Liver Fibrogenesis. Oncotarget. 2016; 7(52):86198-86210. (Q1, SCI IF: 5.0)

3.       Wan LY, Zhang YQ, Li JM, Tang HQ, Chen MD, Ni YR, Huang H, Liu CB*, Wu JF*. Liganded Vitamin D Receptor through its Interacting Repressor Binding to E-box Type VDRE to Inhibits the Expression of Type I Collagen alpha1. DNA CELL BIOL. 2016; 35(9): 498-505. (Q4, SCI IF: 2.574)

4.       Wang H, Ma JL, Yang YG, Song Y, Wu J, Qin YY, Zhao XL, Wang J, Zou LL, Wu JF, Li JM, Liu CB*. Efficient therapeutic delivery by a novel cell-permeant peptide derived from KDM4A protein for antitumor and antifibrosis. Oncotarget. 2016; 7(31):49075-49090. (Q1, SCI IF: 5.0)

5.       Jia D, Ni YR, Zhang YQ, Rao C, Hou J, Tang HQ, Liu CB*, Wu JF*. SP1 and UTE1 Decoy ODNs inhibit activation and proliferation of hepatic stellate cells by targeting tissue inhibitors of metalloproteinase 1. Cell Biosci. 2016 May 10;6:31. doi: 10.1186/s13578-016-0094-6. (Q3, SCI IF: 3.63)

6.       Wang H, Ma J, Yang Y, Zeng F, Liu C*. Highly Efficient Delivery of Functional Cargoes by a Novel Cell-Penetrating Peptide Derived from SP140-Like Protein. Bioconjug Chem. 2016 May 18;27(5):1373-1381. (Q2, SCI IF: 4.513)

7.       Wang H*, Zhang M, Zeng F, Liu C*. Hyperosmotic treatment synergistically boost efficiency of cell-permeable peptides. Oncotarget. 2016;7(46): 74648-74657. (Q1, SCI IF: 5.0)

8.       Liu H, Zeng F, Zhang M, Huang F, Wang J, Guo J, Liu C*, Wang H*. Emerging landscape of cell penetrating peptide in reprogramming and gene editing. J Control Release. 2016;226:124-137. (Q1, SCI IF: 7.705).

9.       Li C, Jiang W, Hu Q, Li LC, Dong L, Chen R, Zhang Y, Tang Y, Thrasher JB, Liu CB, Li B. Enhancing DPYSL3 gene expression via a promoter-targeted small activating RNA approach suppresses cancer cell motility and metastasis. Oncotarget. 2016;7(16):22893-22910. (Q1, SCI IF: 5.0)

10.   Wan LY, Zhang YQ, Chen MD, Du YQ, Liu CB*, Wu JF*. Relationship between Structure and Conformational Change of the Vitamin D Receptor Ligand Binding Domain in 1alpha,25-Dihydroxyvitamin D3 Signaling. Molecules. 2015;20(11):20473-20486. (Q4, SCI IF: 2.416)

11.   Wan LY, Zhang YQ, Chen MD, Liu CB*, Wu JF*. Relationship of structure and function of DNA-binding domain in vitamin D receptor. Molecules. 2015 Jul 7;20(7):12389-12399. (Q4, SCI IF: 2.416)

12.   Ma JL, Wang H, Wang YL, Luo YH, Liu CB*. Enhanced peptide delivery into cells by using the synergistic effects of a cell-penetrating peptide and a chemical drug to alter cell permeability. Mol Pharm. 2015; 12:2040-2048. (Q1, SCI IF: 4.384)

13.   Zhang K, Zhang YQ, Ai WB, Hu QT, Zhang QJ, Wan LY, Wang XL, Liu CB, Wu JF*. Hes1, an important gene for activation of hepatic stellate cells, is regulated by Notch1 and TGF-β/BMP signaling. World J Gastroenterol. 2015;21(3):878-887. (Q4, SCI IF: 2.369)

14.   Zeng F, Huang F, Guo J, Hu X, Liu C*, Wang H*. Emerging methods to generate artificial germ cells from stem cells. Biol Reprod. 2015;92(4):89-97. (Q3, SCI IF: 3.318)

15.   Deng XY, Wang H, Wang T, Fang XT, Zou LL, Li ZY*, and Liu CB*. Non-Viral Methods For Generating Integration-Free, Induced Pluripotent Stem Cells. Curr Stem Cell Res Ther. 2015;10(2):153-158. (Q3, SCI IF: 2.212).

16.   Li XY, Wang MZ, Liu CB*, Jing X, Huang YB*.  TAT-modified mixed micelles as biodegradable targeting and delivering system for cancer therapeutics. J. Appl. Polym. Sci. 2013; 130(6):4598-4607.  (共同通讯作者,Q4, SCI IF: 1.768).

17.   Zou LL, Ma JL, Wang T, Yang TB and Liu CB*. Cell-Penetrating Peptide-Mediated Therapeutic Molecule Delivery into the Central Nervous System. Curr Neuropharmacol. 2013; 11:197-208. (Q4, SCI IF: 3.753).

18.   Wu HY, Han Y, Qin Y, Cao CY, Xia Y, Liu CB, Wang Y*. Whole-cell vaccine coated with recombinant calreticulin enhances activation of dendritic cells and induces tumour-specific immune responses. Oncology reports. 2013; 29(2):529-534. (Q4, SCI IF:2.486).

19.   Li T, Han R, Wang M, Liu C*, Jing X, Huang Y*. Fusiform Micelles from Nonlinear Poly(ethylene glycol)/Polylactide Copolymers as Biodegradable Drug Carriers. Macromol Biosci. 2011; 11(11): 1570-1578. (共同通讯作者,Q2, SCI IF: 3.851).

20.   Wang H, Zhong CY, Wu JF, Huang YB*, Liu CB*. Enhancement of TAT cell membrane penetration efficiency by dimethyl sulphoxide. J Control Release. 2010; 143(1):64-70.  (Q1, SCI IF: 7.705).

主要专利:

1细胞穿膜肽hPP10及其用途。专利号:ZL201210267050.72014.07.30授权) 

2)细胞穿膜肽hPP10的生产及其介导质粒DNA转染的方法。专利号:201210267005.1 2014.07.30授权)

3人源性细胞穿膜肽hPP3及其用途。专利号:ZL201310166067.82014.11.06授权)

4) 细胞穿膜肽hPP5及其用途。(实审公示中)

5) 细胞穿膜肽hPP8及其用途。(实审公示中)


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